How Calmare works? Calmare is basically a Transcutaneous Electrical Modulation Pain Reprocessing (TEMPR) device. Surface electrodes are placed on the skin in a non-painful area. A signal is sent through those electrodes into the nerve fibers that travel along the spinal cord to the brain letting the brain know there is NO PAIN! It is really that simple. There are no side effects. No addiction occurs using this mode of therapy. This is a completely noninvasive treatment to relieve chronic nerve pain as well as other maladies.